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  • Integra 3 Micromanipulator
  • Integra 3TM Micromanipulator

    Every detail of the Integra 3 is geared towards one goal – to ensure you create the best possible conditions for ICSI and sample manipulation.

    We recognise that temperature and time are critical within an ART lab.  Integra 3 is ultra-responsive and effortlessly smooth, so it’s quick and easy to use, thanks to RI’s advanced mechanical design.  You can change micropipettes in seconds, which can transform the efficiency of your lab overnight.

    We have increased the size of the integrated heated stage by 40% but kept the footprint to a minimum to keep your work area uncluttered.

    This product is available for sale in the U.S.A and selected countries in Europe and the rest of the world.

    “By far the best new feature is the warm air flow through the central plate – which means your dish can maintain the correct temperature throughout the procedure. The egg counter feature has also been a blessing in large cases, as well as the warning “beeps” for the fine manipulator height indicator”

    Sophie Bird – Embryologist, Guy’s and St.Thomas’ NHS Foundation Trust

    Thermosafe™ is an integral heating system that helps to keep samples at the optimum temperature. It emits warm air precisely and uniformly towards the Petri dish.

    The result of this is a fail-safe guarantee, with no more cold spots, no more hot spots and no more ambiguity.

    There is also a stage temperature health indicator light to reassure you that the integrated heating system is functioning correctly.

    ThermosafeTM – Ultimate Thermal Control for Integra 3TM

    Thermal image of Petri dish surface when placed on heated metal plate WITH THERMOSAFE

    Petri dish surface when placed on heated metal plate WITHOUT THERMOSAFE™

    Petri dish surface when placed on market leading glass ITO WITHOUT THERMOSAFE™


    Key Features

    No Cold Spots

    Thermosafe™ maintains sample temperature with a gentle stream of warm air under the Petri dish


    Improved rapid micropipette set-up with one-step angle adjustment


    Motion sensor LED light underneath the stage for improved visibility when changing objectives


    Heating system status indicator light and alarm monitors every second of the process.  A log is kept of every alarm triggered


    Large built-in mechanical XY stage plus temperature controllers with easy access buttons and touch screen


    New extra-fine mechanisms for smooth and precise movement of the stage and micropipettes

    Integra 3TM

    The Definitive Micromanipulator

    We’ve added a whole spectrum of other functions and features that make the Integra 3™ an intuitive and ergonomic mechanical micromanipulation system. View our Integra 3™ film to find out more.

    Additional Functions and Features

    Colour Touch Screen

    Using the 3.5 inch touch screen display, you can check temperature, track time with a stop watch and count the number of injections done.  The electronic height indicators track the vertical position of the tool holders.

    Shortcut Video And Images

    If you need to keep track of samples or procedures, just hit the shortcut buttons to film or photograph any stage of the process.  There’s a counter button and an onscreen stopwatch as well.

    Motion Triggered LED Light

    A motion triggered light illuminates under the stage as soon as it detects your hand, to help you see when changing objectives.

    Precise And Intuitive Control

    When you perform ART micromanipulation procedures, accuracy is paramount.  Integra 3™ offers the finest possible movement on the XYM stage and fine and coarse levers as well as a choice of oil or air syringes for the control of samples.

    RI ViewerTM Software

    You can use the Integra 3™ without a computer or camera.  However, if you connect it to a computer, we can supply the RI Viewer™ software. With RI Viewer™ you can use the shortcut keys.  Enjoy razor-sharp full screen imaging from the microscope, with digital magnification and a modern, clean user interface.

    It also offers line measurement tools and a built-in simulator for training and demonstration purposes.  RI Viewer™ also allows you to sync up with Saturn™ laser and RI IMSI™ systems.


    The Integra 3™ includes two of our SAS air syringes as standard.  These syringes offer superb control and eliminate the need for oil. Also available is the SAS-SE for superfine air control or our SOS oil syringe with a quick fill feature for minimum set-up time.

    Microscope Compatibility


    TMD, Diaphot 200/300 TE2000, TE200/300, Ti


    DMIRB, DMI3000B/4000B/6000B DM IL, DMi8


    IMT2, IX50/70 IX51/71/81, IX53/73/83


    Axiovert 40/100/200 Axio Observer, Axio Vert.A1

    * Contact us if your microscope is not listed

    Heating System
    Thermosafe™ Air Heating System with Heated Metal Insert:
    25mm aperture (standard)
    16mm aperture (optional)
    ITO Heated Glass Insert (optional)
    Temperature Controller
    Accuracy: better than ±0.1ºC when calibrated against known reference
    Resolution: 0.1ºC
    Setpoint Temperature Range: 30-45ºC
    3.5″ colour LCD touch screen display for temperature control
    USB socket for connection to PC running RI Viewer™ software
    Choice of SAS (air), SAS-SE (air) and SOS (oil)
    Maximum weight of microscope mounted components (excluding front and rear adaptors): 10.4kg
    Actual weight is configuration dependent
    Footprint (not including microscope): width 56cm, depth 38cm
    Power Supply
    Input: 100-240VAC, 50-60HZ, Max. 1.8A, Class 1
    Output: 12VDC, Min. 11A (132W)
    Operating Range
    Temperature: 15ºC (59ºF) to 40ºC (104ºF)
    Humidity:15% to 85% RH (non condensing)
    Micropipette Compatibility
    Compatible with Research Instruments micropipettes (or other industry standard 1.0mm outside diameter micropipettes or equivalent specification).

    Please use the table below to select the correct part number for your equipment.

    Microscope Manufacturer Model Syringe Choice Part Number Description
    Nikon Ti2 None 6-54-100-14 Integra 3 Thermosafe Nikon
    No Syringes
    Nikon Ti2 2 x SAS 6-54-100-15 Integra 3 Thermosafe Nikon
    2 x SAS
    Nikon Ti2 1 x SAS,
    1 x SAS-SE
    6-54-100-16 Integra 3 Thermosafe Nikon
    1  x SAS 1 x SAS-SE
    Nikon Ti2 2 x SAS-SE 6-54-100-17 Integra 3 Thermosafe Nikon
    2 x SAS-SE
    Nikon Ti-S, Ti-U, Ti-E
    TE2000,TE200, TE300
    None 6-54-100-01 Integra 3 Thermosafe Nikon
    No Syringes
    Nikon Ti-S, Ti-U, Ti-E,TE2000,TE200, TE300 2 x SAS 6-54-100-02 Integra 3 Thermosafe Nikon
    2 x SAS
    Nikon Ti-S, Ti-U, Ti-E,TE2000,TE200, TE300 1 x SAS,
    1 x SAS-SE
    6-54-100-03 Integra 3 Thermosafe Nikon
    1 x SAS , 1 x SAS-SE
    Nikon Ti-S, Ti-U, Ti-E,TE2000,TE200, TE300 2 x SAS-SE 6-54-100-04 Integra 3 Thermosafe Nikon
    2 x SAS-SE
    Olympus IX53, IX73, IX83,IX51, IX71, IX81 None 6-54-100-05 Integra 3 Thermosafe Olympus
    No Syringes
    Olympus IX53, IX73, IX83,IX51, IX71, IX81 2 x SAS 6-54-100-06 Integra 3 Thermosafe Olympus
    2 x SAS
    Olympus IX53, IX73, IX83,IX51, IX71, IX81 1 x SAS,
    1 x SAS-SE
    6-54-100-07 Integra 3 Thermosafe Olympus
    1 x SAS, 1 x SAS-SE
    Olympus IX53, IX73, IX83,IX51, IX71, IX81 2 x SAS-SE 6-54-100-08 Integra 3 Thermosafe Olympus
    2 x SAS-SE
    Olympus IX50, IX70 2 x SAS 6-54-100-13 Integra 3 Thermosafe Olympus IX1
    2 x SAS
    Olympus IX1 Series None 6-54-100-18 Integra 3 Thermosafe Olympus IX1
    No Syringes
    Leica DMi8, DMIx000B, DMIRB None 6-54-100-09 Integra 3 Thermosafe Leica
    No Syringes
    Leica DMi8, DMIx000B, DMIRB 2 x SAS 6-54-100-10 Integra 3 Thermosafe Leica
    2 x SAS
    Leica DMi8, DMIx000B, DMIRB 1 x SAS,
    1 x SAS-SE
    6-54-100-11 Integra 3 Thermosafe Leica
    1 x SAS, 1 x SAS-SE
    Leica DMi8, DMIx000B, DMIRB 2 x SAS-SE 6-54-100-12 Integra 3 Thermosafe Leica
    2 x SAS-SE
    Leica DMi8, DMIx000B, DMIRB 2 x SAS 6-54-110-01 Integra 3 No Thermosafe Leica
    2 x SAS
    Leica DMi8, DMIx000B, DMIRB 2 x SAS 6-54-110-12 Integra 3 ITO Leica
    2 x SAS
    Q. What are the advantages of the Integra 3™?
    A. The Integra 3™ has very natural and intuitive controls. It has a quick and easy micropipette set-up procedure, with the ability to change the micropipette angle with a single control. It is also compact and takes up very little laboratory bench-top space, whilst providing a large stage surface area to work on. Thermosafe™ ensures consistent temperature, including in the microscope line of sight, to provide stable temperature during micromanipulation.

    Q. How easy is it for a customer to change over to RI if they have never used the Integra 3™ before?
    A. Very easy – most people convert perfectly after a couple of sessions. You have to get used to new hand positions, but this takes very little time and once mastered, the control is superb and the operation much quicker.

    Q .What is included in the system?
    A. The Integra 3™ comes as standard with: 2 x micromanipulators incorporating coarse and fine controls, 2 x toolholders with easy micropipette set-up, 1 x large heated stage, 1 x Thermosafe™ warm air heating system (option available without Thermosafe™), 1 x 3-channel temperature controller with improved touch screen control, 2 x SAS syringes / injectors, 2 x handrests, 1 x mechanical XY stage.  Optional extras: Glass heated stage insert, extra-smooth air syringe (SAS-SE) or oil syringe (SOS), microscope camera, PC / monitor, RI imaging software RI Viewer™.

    Q. What if we wish to use existing syringes or syringes from another company?
    A. We have adaptors which allow existing syringes to be used with the Integra 3™.

    Q. Can RI provide training?
    A. We can provide instruction on how to use the equipment at installation, and can also arrange a training session at a current user’s lab, or arrange for an experienced embryologist to visit your lab. This is equipment training only. If clinical procedure training is needed, we can put you in touch with laboratories who offer this service.

    Q. Why would Thermosafe™ be useful?
    A. Maintaining even temperatures during micromanipulation helps preserve the best conditions for the samples even outside of the incubator. Please refer to “Can temperature stability be improved during micromanipulation procedures by introducing a novel air warming system?”, 2014, Wheat S, Vaughan K, Harbottle S.” and Integra TI vs Integra 3 (I3): a prospective randomised sibling study assessing fertilisation outcome, embryo quality and morphokinetic parameters”, 2014, Gwinnett D, Cook C, Escriba M, Hickman C, Trew G, Lavery S.